is an antiretroviral (protease inhibitor) medication
used in the treatment of HIV infections. It
easily precipitates to form crystals. People
who take this drug are instructed to drink large
amounts of water in order to create a large urine
volume which helps to dissolve the medication in the
can be difficult. Many patients who come in
of kidney stones are likely to have a CT scan or
an xray of the kidneys which may not show indinavir
stones. Indinavir stones often are difficult
to detect on these tests. However, they should
be visible on an ultrasound. It is critical to
differentiate these stones from uric acid stones
which sometimes can also be difficult to detect.
Uric acid stones are treated with citrate (alkali)
therapy to raise urine pH (decrease acidity) while
this same treatment could actually promote formation
of Crixivan stones.
treating people with HIV and uric acid stones,
should consider prescribing a medication other than
indinavir if possible.